题目：How proteins interact in bioinformatics
时间：2011年5月16日下午4：00
地点：学六五楼会议室
报告人：Joel Janin：
Emeritus Professsor of Biophysics at the Yeast Structural Genomics Laboratory,UniversitéParis-Sud, Orsay，France. Author of two textbooks and over 180 publications.
A student in solid state physics at Ecole Normale Supérieure in Paris, joined Cy Levinthal at MIT in 1964 to learn molecular biology, and returned to France a year after to do a Ph.D. in Enzymology with Georges Cohen (Universitéde Paris, 1969). Was introduced to crystallography and the field of protein-protein interaction during a post-doc with David Blow at the MRC Laboratory of Molecular Biology (Cambridge, UK) in 1973-74. Became Professor of Biophysics in UniversitéParis-Sud, Orsay in 1981 and started protein crystallography; served as the head of the CNRS Laboratoire de Biochimie et Enzymologie Structurales (1992-2005); initiated structural genomics in Orsay on 2000.
报告主要内容：
Protein–protein recognition plays an essential role in structure and function. Specific non-covalent interactions stabilize the structure of macromolecular assemblies, exemplified in this review by oligomeric proteins and the capsids of icosahedral viruses. They also allow proteins to form complexes that have a very wide range of stability and lifetimes and are involved in all cellular processes. We present some of the structure-based computational methods that have been developed to characterize the quaternary structure of oligomeric proteins and other molecular assemblies and analyze the properties of the interfaces between the subunits. We compare the size, the chemical and amino acid compositions and the atomic packing of the subunit interfaces of protein–protein complexes, oligomeric proteins, viral capsids and protein–nucleic acid complexes. These biologically significant interfaces are generally close-packed, whereas the non-specific interfaces between molecules in protein crystals are loosely packed, an observation that gives a structural basis to specific recognition. A distinction is made within each interface between a core that contains buried atoms and a solvent accessible rim. The core and the rim differ in their amino acid composition and their conservation in evolution, and the distinction helps correlating the structural data with the results of site-directed mutagenesis and in vitro studies of self-assembly.
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