韩之刚，博士，副教授，硕士生导师。

研究方向

围绕药用植物天然活性成分生物合成，从基因组解析、生物大数据与优异资源发掘利用、关键途径酶的理性设计与改造开展研究：

（1）药用植物基因组及天然活性成分合成途径解析

（2）植物次生代谢途径关键酶的演化规律及改造

（3）生物大数据深度学习模型构建及智能育种设计

学习与工作经历

2024.01-至今，永利3044官网，副教授

2020.09-2023.12，永利3044官网，永利3044官网，讲师

2018.07-2020.07，浙江大学，作物科学研究所，助理研究员

2013.09-2018.06，浙江大学，作物学，硕博连读

2008.09-2012.06，青岛农业大学，植物科学与技术，学士

教学工作

本科生课程

《生物计算机编程》、《植物基因组学》、《测序原理与数据分析》

研究生课程

《药用植物遗传育种》

主持科研项目

1.国家自然科学基金，青年基金项目，32200214,多花黄精氧甲基转移酶PcOMT在高异黄酮合成中的作用机制研究，30万元，2023-01至2025-12，在研，主持

2.国家科技部，重点研发任务，2022YFD220060，苏木高异黄酮调控及生物合成转化机制解，60.1万元，2022-11至2026-10，在研，主持

3.浙江省自然科学基金，青年探索，LQ22H280003，多花黄精PcOMT1基因在高异黄酮碳骨架形成中的分子机制，10万元，2022-01至2024-12，在研，主持

4.永利3044官网学校科研发展基金，2023PY013，基于多花黄精基因组的淀粉与果聚糖转化机制，40万元，2023.07至2024.12，40万元，在研，主要参与人

5.中国博士后科学基金会，面上二等资助项目，2018M642446，西藏野生大麦多酚合成相关基因HvKFB01的功能鉴定，2018-11至2020-07，5万元，结题，主持

6.浙江农林大大学学校科研发展基金项目，2020FR072，茉莉酸甲酯介导铁皮石斛葡甘露聚糖合成机制研究，2020-09至2022-12，10万元，结题，主持

论文与专著

第一作者或通讯作者论文

1.Han, Z., Xu, Z., Xu, Y., Lin, J., Chen, X., Wang, Y., ... & Si, J. (2024). Phylogenomics reveal DcTPS-mediated terpenoid accumulation and environmental response inDendrobium catenatum. Industrial Crops and Products, 208, 117799.（中科院1区TOP，IF=5.9）

2. Li, C., Gong, Q., Liu, P., Xu, Z., Yu, Q., Dai, H., ... &Han, Z.(2024). Co-expressed network analysis based on 289 transcriptome samples reveals methyl jasmonate-mediated gene regulatory mechanism of flavonoid compounds inDendrobium catenatum. Plant Physiology and Biochemistry, 206, 108226.（中科院2区TOP，IF=6.5）

3.Han, Z., Gong, Q., Huang, S., Meng, X., Xu, Y., Li, L., ... & Si, J. (2023). Machine learning uncovers accumulation mechanism of flavonoid compounds inPolygonatum cyrtonemaHua. Plant Physiology and Biochemistry, 107839.（中科院2区TOP，IF=6.5）

4. Li, C., Cai, X., Shen, Q., Chen, X., Xu, M., Ye, T.,Han, Z.*, & Si, J*. (2022). Genome-wide analysis of basic helix–loop–helix genes inDendrobium catenatumand functional characterization of DcMYC2 in jasmonate-mediated immunity toSclerotium delphinii. Frontiers in Plant Science, 13. (中科院2区TOP，IF=5.6)

5. Zhang, S., Li, C., Si, J.,Han, Z.*, & Chen, D*. (2022). Action mechanisms of effectors in plant-pathogen interaction. International Journal of Molecular Sciences, 23(12), 6758. (中科院2区TOP，IF=5.6)

6. Li, L., Xu, Y., Chen, X., Bao, H., Li, C., Zhang, X., ... &Han, Z. (2022). Weighted gene co-expression network analysis revealed the synthesis of aromatic compounds inDendrobium catenatum. Industrial Crops and Products, 178, 114668. (中科院1区TOP，IF=5.9)

7.Han Z., Ahsan M., Adil M., Chen X., Nazir M., Shamsi I., Zeng F., & Zhang G. (2020) Identification of the gene network modules highly associated with the synthesis of phenolics compounds in barley by transcriptome and metabolome analysis. Food chemistry, 323. (中科院1区TOP，IF=8.8)

8.Han Z., Gao H., Ye L., Adil M., Ahsan M., Zhang G. (2019) Identification of QTLs associated with phenolic acids and structure analysis of candidate genes in barley. Euphytica. (中科院3区，IF=1.9)

9.Han Z., Zhang J., Cai S., Chen X., Quan X., & Zhang G. (2018). Association mapping for total polyphenol content, total flavonoid content and antioxidant activity in barley. BMC genomics, 19(1), 81. (中科院2区TOP，IF=4.4)

10.Han Z., Cai S., Zhang X., Qian Q., Huang Y., Dai F., & Zhang G. (2017). Development of predictive models for total phenolics and free p-coumaric acid contents in barley grain by near-infrared spectroscopy. Food chemistry, 227, 342-348. (中科院1区TOP，IF=8.8)

11. Cai S.*, Han Z.*, Huang Y., Chen Z, Zhang, G, & Dai, F (2015). Genetic diversity of individual phenolic acids in barley and their correlation with barley malt quality. Journal of agricultural and food chemistry, 63(31), 7051-7057. (中科院1区TOP，IF=6.1)

参与论文：

1.Wang, Y., Chen, G., Zeng, F.,Han, Z., Qiu, C. W., Zeng, M., ... & Chen, Z. H. (2023). Molecular evidence for adaptive evolution of drought tolerance in wild cereals. New Phytologist, 237(2), 497-514. (中科院1区TOP，IF=9.4)

2.Cai, S., Shen, Q., Huang, Y.,Han, Z., Wu, D., Chen, Z. H., ... & Zhang, G. (2021). Multi‐Omics Analysis Reveals the Mechanism Underlying the Edaphic Adaptation in Wild Barley at Evolution Slope (Tabigha). Advanced Science, 8(20), 2101374. (中科院1区TOP，IF= 15.1)

3.Chen, D.,Han, Z., & Si, J. (2021). Huangjing (Polygonati rhizoma) is an emerging crop with great potential to fight chronic and hidden hunger. Science China. Life Sciences, 64(9), 1564. (中科院1区TOP，IF=9.1)

4.Cai S., Han Z., Huang Y., Hu H., Dai F., & Zhang G. (2016). Identification of quantitative trait loci for the phenolic acid contents and their association with agronomic traits in Tibetan wild barley. Journal of agricultural and food chemistry, 64(4), 980-987. (中科院1区TOP，IF=6.1)

联系方式

通讯地址：浙江省杭州市临安区武肃街666号永利3044官网东湖校区国重楼309室

邮 编：311300

电 话：18258104152

邮 箱：hanzg@zafu.edu.cn